研究方向 1. 大分子药物口服递送研究;2. 创新制剂研究及疾病精准治疗。 主持国家自然科学基金、四川省科技厅项目、成都市科技局重点研发项目、成都市卫健委项目、成都市第三人民医院菁英PI等项目。以第一作者、通讯作者在权威期刊Acta Pharmaceutica Sinica B、Biomaterials、 Applied Materials & Interfaces、Journal of Materials Chemistry B 等发表SCI论文。 本课题组常年招收科研助理,要求具药学类、生物技术与生物科学、化学、材料、工程、免疫学等相关背景。请有意向者请将个人简历、过往研究内容概述、拟开展研究方向概述、近五年发表论文等资料发送至邮箱:ZhengYX95@163.com
代表论文: Yaxian Zheng, Shiqin Luo1, Min Xu, Qin He, Jiang Xie, Jiawei Wu*, Yuan Huang*.Transepithelial Transport of Nanoparticles in Oral Drug Delivery: From the Perspective of Surface and Holistic Property Modulation [J]. Acta Pharmaceutica Sinica B,2024,14(9):3876-3900.(IF 14.7)
Ziqing Xiong, Qi An, Liqiang Chen, Yucheng Xiang, Lian Li* and Yaxian Zheng*. Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types [J]. Journal of materials chemistry B, 2023,11(41):9867-9888.(IF 7.0)
Yaxian Zheng,Liyun Xing,Liqiang Chen,Rui Zhou,Jiawei Wu,Xi Zhu,Lian Li,Yucheng Xiang,Ruinan Wu,Ling Zhang* and Yuan Huang*.Tailored Elasticity Combined with Biomimetic Surface Promotes the Transcytosis of Nanoparticles to Overcome Mucosal Epithelial Barrier [J]. Biomaterials, 2020, 262, 120323. (IF 12.8)
Yaxian Zheng, Jiawei Wu, Wei Shan, Lei Wu, Rui Zhou, Min Liu, Yi Cui, Minglu Zhou, Zhirong Zhang, and Yuan Huang*. Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway [J]. ACS applied materials & interfaces, 2018, 10(40): 34039-34049. (IF 10.3)
Yining Xu#, Yaxian Zheng#, Lei Wu, Xi Zhu, Zhirong Zhang, and Yuan Huang* Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin [J]. ACS applied materials & interfaces, 2018, 10(11): 9315-9324. (共同第一作者,IF 10.3)